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Dr. Korogod S.M. group: COMPUTER MODELLING
Our general research interest is in the relationship between structure and function of neurons at cellular and sub-cellular levels. Our technique is computer simulation, which we associated with natural experiments in our partners laboratories. At the cellular level, we study the impact of geometry and kinetic properties of the membrane and intracellular physical-chemical processes on generation of the spatial and temporal patterns of electrical and biochemical signals in neurons with complex dendritic arborizations. In our computer simulation studies on reconstructed neurons from different parts of the brain and spinal cord, we test the hypothesis that the complexity and metrical asymmetry of the dendritic arborizations are structural determinants of richness of the repertoire of spatial-temporal patterns of the neuronal output activity. At the sub-cellular level, we are interested in revealing the impact of surface-to-volume relations between cellular compartments and organellar ion stores as structural determinants of spatial-temporal concentration patterns during evoked and intrinsic (self-maintained) activities. |
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